McCaffrey’s season ‘potentially’ over after knee injury

ORCHARD PARK, N.Y. — San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

Shanahan said McCaffrey is believed to have injured his posterior cruciate ligament, which connects the thigh bone to the shin. He said he had no timetable for McCaffrey’s return but acknowledged the All-Pro’s season could be over.

“I think PCL is usually a couple weeks, but I’m not exactly sure yet,” Shanahan said.

It’s the latest setback in a frustrating season for the 2023 offensive player of the year, who missed the Niners’ first eight games with Achilles tendinitis and has not been his usual explosive self since returning. And it’s another blow for a team that has battled injuries all season, was missing five starters against Buffalo and dropped its third straight.

San Francisco (5-7) sits alone in last in the NFC West standings, two wins behind division-leading Seattle, and in jeopardy of missing the playoffs a year after losing to Kansas City in the Super Bowl.

“He’s one of the best running backs in the league,” quarterback Brock Purdy said. “When you lose him like that, I think it takes away just sort of how we do some things in the offense.”

McCaffrey stepped awkwardly on a sweep to the left on a snow-slicked field and went down almost immediately for a 5-yard loss. He went to the sideline and was examined in the medical tent before limping toward the locker room. The Niners announced before the start of the third quarter that he would not return.

Shanahan said he believes McCaffrey hurt his knee when he got tackled by Taylor Rapp at the end of an 18-yard run earlier in the drive.

“It looked like he just got shoe-stringed there, he was about to break a house call,” Shanahan said. “It was frustrating. He had a great week of practice. I could feel his urgency and stuff. Thought he came out great, looking real good.”

McCaffrey’s 19-yard run in the first quarter was his longest of the season, and he had seven carries for 53 yards and two catches for 14 yards before getting hurt.

“He was on fire man,” Purdy said. “He looked great, hitting the holes hard, bouncing off guys, and making some great plays.”

Very little went right for the 49ers in a game that was played in wintry conditions, with snow falling throughout the night.

Jake Moody missed two of three field-goal attempts.